International Mast Cell and Basophil Meeting 2011 in partnership to the COST Annual Conference on Mast Cells and Basophils 2011

24-25th November, 2011, Southampton, UK. Mast Cells and Basophils as Targets for Innovative Therapies.

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Meeting hosted by the European Mast Cell and Basophil Research Network (EMBRN) and European Cooperation in Science and Technology (COST) Action 1007.
Registration is now open online at: EMBRN-COST International Mast Cell and Basophil meeting (click on ‘Book Event’)

Abstract submission has been expired on 31 October 2011.

 

 

Scientific programme

Wednesday, 23rd November 2011
17.00 – 21.00	Registration desk open Poster set up

Thursday, 24th November 2011
8.00 – 9.00	Registration Tea and coffee with pastries Poster set up
9.00 – 9.30	Welcome Andrew F Walls, Southampton, President of Southampton Meeting Marcus Maurer, Berlin, Chair of COST Action Stephan Bischoff, Stuttgart, President of EMBRN
Session A: Highlights in mast cell and basophil research I (Chairs: Gunnar Pejler, Uppsala and Marcus Maurer, Berlin)
9.30 – 10.00	Rick L Stevens, Boston: Importance of mast cell-restricted proteases in innate immunity, inflammation, and blood coagulation (O1)
10.00 - 10.30	Jean S. Marshall, Halifax: Models of viral infection and cancer reveal novel roles for mast cells in effector cell recruitment (O2)
10.30 – 10.50	Gunnar Nilsson, Stockholm: Increased vascular permeability by mast cells mediated by heparin-initiated bradykinin formation (O3)
10.50 – 11.00	Tea and coffee with biscuits
Session B: Work Group 1 Symposium: Physiological and pathophysiological importance of mast cells and basophils in health and disease. Insights into mast cell and basophil signal transduction pathways (Chairs: Francesca Levi-Schaffer, Jerusalem and Nicolas Charles, Paris)
11.20 – 11.40	Petr Draber, Prague: STIM1-cytoskeleton cross-talk in mast cell movement and degranulation (O4)
11.40 – 12.00	Didier Ebo, Antwerp: Flow-assisted analysis of in vitro activated basophils (O5)
12.00 – 12.20	Araceli Tobio Ageitos, Santiago de Compostela: C-kit mutations and PKC crosstalk: PKC translocates to nucleus only in HMC-1560,816 cells (O6)
12.20 – 12.30	Thomas A Brown, Southampton: Mast Cell Carboxypeptidase: A Marker for the Diagnosis of Drug-Induced Allergic Reactions and for Predicting which Patients are at Risk (O7)
12.30 – 12.40	Jolien Suurmond, Leiden: Toll-Like Receptor triggering can synergize with IgE-mediated activation of human mast cells in autoimmunity (O8)
12.40 – 12.50	Matthias Mack, Regensburg: Basophils control T cell responses and experimental colitis in mice (O9)
12.50 – 13.50	Buffet lunch
Session C: Highlights in mast cell and basophil research II (Chairs: Peter Bradding, Leicester and Per Stahl Skov, Copenhagen )
13.50 – 14.20	Hirohisa Saito, Tokyo: The mast cell and basophil transcriptome (O10)
Session D: Work Group 2 Symposium: Methodological approaches for the investigation of mast cell and basophil biology (Chairs: Franco H. Falcone, Nottingham and Karin Hartmann, Cologne)
14.20 – 14.40	Axel Roers, Dresden: Novel mouse models for the investigation of mast cell in vivo functions (O11)
14.40 – 15.00	Franco H. Falcone, Nottingham: Purification of peripheral blood basophils from human blood (12)
15.00 – 15.20	Vadim Sumbayev, Chatham Maritime: RNA silencing in primary mast cells and basophils (13)
15.20 - 15.30	Ahmed Fawzy, Southampton: Development and Characterisation of BB5, a New Basophil-Specific Monoclonal Antibody that Binds to Basogranulin (O14)
15.30 - 15.40	Lucie Potakuckova, Prague: Functionalized gold nanoparticle-based immuno-PCR, a new method for sensitive detection of cytokines produced or utilized by mast cells (O15)
15.40 - 15.50	Hans-Jürgen Hoffmann, Aarhus: Basophil Sensitivity Decreases in Parallel with Clinical Sensitivity in Allergen Challenge during Subcutaneous Immunotherapy (SCIT) in Subjects Allergic to Grass Pollen (O16)
15.50 - 16.20	Tea and coffee with cake
15.50 - 17.10	Poster Viewing: All poster presenters present Posters listed below Work Group 1: Poster walk by Frank Redegeld, Utrecht  and Ronit Sagi-Eisenberg, Tel Aviv Work Group 2: Poster walk by Franco Falcone, Nottingham Work Group 3: Poster walk by Bernhard Gibbs, Chatham Maritime and Jenny Hallgren, Uppsala Work Group 4: Poster walk by Tilo Biedermann, Tübingen and Jane Warner, Southampton
17.10 – 17.40	Separate Meetings for COST Work Groups 1, 2, 3 and 4 (Main Meeting Room)
17.40 – 18.40	Joint business meeting of COST working groups COST Management Committee Meeting
19.10	Social Event – Buses leave for HMS Warrior

Friday, 25th November 2011
7.30 – 8.30	Board of Directors of EMBRN and COST Management Committee Meeting (Allertons Room, situated off the Main Restaurant, Grand Harbour Hotel)
8.30 – 9.00	Tea and coffee with pastries
Session E: Highlights in mast cell and basophil research III (Chairs: Carlo Pucillo, Udine and Bernhard Gibbs, Chatham Maritime)
9.00 – 9.30	Hajime Karasuyama, Tokyo.  Emerging roles of basophils in protective and pathological immune responses (O17)
Session F: Work Group 3 Symposium: Identification of biological and pharmaceutical mast cell and basophil related targets (Chairs: Bernhard Gibbs, Chatham Maritime and Jenny Hallgren, Uppsala)
9.30 – 9.50	Nicolas Charles, Paris: Basophils and Autoimmunity: Making sense of IgE in lupus (O18)
9.50 – 10.10	Peter Peachell, Sheffield: Human lung mast cell releasability: role of syk (O19)
10.10 – 10.30	Silvia Bulfone-Paus, Borstel: The role of coronins in the control of mast cell activation (O20)
10.30 – 10.40	Gianni García-Faroldi, Uppsala: ADAMTS: novel proteases expressed by activated mast cells (O21)
10.40 – 10.50	Axel Lorentz, Stuttgart: Complexin II is involved in enhanced exocytosis of human intestinal mast cells following IL-4 priming (O22)
10.50 – 11.00	Ian Ashmole, Leicester: CRACM/Orai ion channel expression and function in human lung mast cells (O23)
11.00 – 11.30	Tea and coffee with biscuits
Session G: Mast cells as Drug Targets (Chairs: Martin Church, Southampton/Berlin and Frank Siebenhaar, Berlin)
11.30 – 11.50	Alan Edwards, Isle of Wight: Landmarks in the Development of Drugs that Target Mast Cells (O24)
11.50 - 12.00	Anja Rabenhorst, Cologne: Mast cells play a pro-tumorigenic role in primary cutaneous lymphoma (O25)
12.00 - 12.10	Luis Escribano, Toledo: Impact of KIT mutation in the evolution of serum basal tryptase levels in indolent systemic mastocytosis. (O26)
12.10 – 12.20	Elizabeth Doyle, Berlin: Tryptase therapy counteracts lethal effects of snake venom: a new treatment for snakebite (O27)
12.20 – 12.30	Giorgia Gri, Udine: AhR stimulation modulates mast cell degranulation and regulatory cytokine response (O28)
12.30 – 12.40	Paul Forsythe, Hamilton: A Pseudomonas aeruginosa derived acyl homoserine lactone promotes and inhibits mast cell responses to stimuli (O29)
12.40 – 12.50	Joakim S Dahlin, Uppsala: CD11c+ cells are required for mast cell progenitor recruitment to lung in a mouse model of allergic airway inflammation (O30)
12.50 – 14.00	Buffet lunch
Session H: Work Group 4 Symposium: Therapeutic potential of mast cell and basophil targeting strategies (Chairs: Stephan Bischoff, Stuttgart and Frank Redegeld, Utrecht)
14.00 – 14.20	Sven-Erik Dahlen, Stockholm: New insight into antagonism of mast cell-dependent responses  (O31)
14.20 – 14.40	Stephen T Holgate, Southampton: Stratified Approaches to Mast Cell Related Therapeutics for Allergic Diseases (O32)
14.40 – 15.00	Clemens A Dahinden, Bern: Mast cell and basophil genechip analyses and consequences for the understanding and management of disease (O33)
15.00 – 15.10	Lars Hellman, Uppsala: Vaccination against IL-33 effectively reduces dermatitis scores on mite allergen induced dermatitis in NC/Nga mice (O34)
15.10 – 15.20	Mattias Enoksson, Stockholm: Intraperitoneal influx of neutrophils in response to IL-33 is mast cell dependent (O35)
15.20 – 15.30	Xiaoying Zhou, Southampton: Anaphylaxis is Associated with Increased Serum Levels of Mast Cell Chymase (O36)
15.30	Tea and coffee with cake available
15.30 - 16.15	EMBRN General Assembly and Closure of Meeting

 

Poster Presentations

Work Group 1

Andrea Dichlberger, Helsinki: Arachidonic acid-induced formation of human mast cell lipid bodies is mediated by long-chain acyl-CoA synthetases (P1)

Vadim V. Sumbayev, Chatham Maritime: The Role of Hypoxia-Inducible Factor 1 and Associated Pathways in Host Innate Immune Defence, Allergic Inflammation, and Leukaemia Progression (P2)

Bernhard F. Gibbs, Chatham Maritime: Regulation of Human Mast Cell and Basophil Responses by Hypoxia-Inducible Factor-1α. (P3)

Cecilia K Andersson, Lund: Alveolar mast cell expression of the high-affinity IgE receptor differs between allergic asthma and rhinitis (P4)

Yu Fang, Gothenburg: Enhancing the effectiveness of vaccine adjuvants by targeting mast cells (P5)

Thomas Hügle, Basel: Mast Cell Fibrogenesis: Direct Vesicle Transmission by Mast Cells to Fibroblasts and Lymphocytes in Systemic Sclerosis (P6)

Qingjun Pan, Zhanjiang: Number and phenotype of circulating basophils for monitoring disease activity in systemic lupus erythematosus (P7)

Helena Horáková, Prague: Regulatory role of the protein 4.1R in mast cell signaling and chemotaxis (P8)

Rohit Saluja, Stockholm: FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment (P9)

Walid H Beghdadi, Paris: Mast cells decrease renal fibrosis in unilateral ureteral obstruction by a murine mast-cell chymase (mMCP4)-dependent mechanism (P10)

Emily J. Swindle, Southampton: Suppression of Mast Cell Activation Following Co-culture With Differentiated Bronchial Epithelial Cells (P11)

Rosa Torres, Barcelona:House dust mite aeroallergens can induce airway pathology in C57BL/6 by means of a mast cell-independent mechanism (P12)

Ulrich Blank, Paris: Critical role of the neutrophil-associated high affinity receptor for IgE in the pathogenesis of experimental cerebral malaria (P13)

Julia A Trosien, Berlin: Anti-inflammatory effects of a polyglycerolsulfate on type I allergic responses (P14)

Ana Claudia Zenclussen, Magdeburg: Mast cells are critical for pregnancy establishment and maintenance (P15)

Federico Jensen, Magdeburg: Female sex hormones induce the migration of mast cells to the uterus and provoke their degranulation (P16)

Nashwan Asmail, Uppsala: Mast cells as regulators of tumor angiogenesis and progression (P17)

Ananya Roy, Uppsala: Serglycin limits enteropathy in Trichinella spiralis-infected mice (P18)

Laura Sánchez-Muñoz, Toledo: Serum carboxypeptidase is a predictive factor of symptoms in children with mastocytosis in the skin (P19)

Xiaoying Zhou, Southampton: Mast Cell Chymase Can Induce Disruption of the Bronchial Epithelium and Loss of Adhesion Molecule Expression (P20)

Osama Sawesi, Uppsala: Serglycin contributes to cytokine secretion during Toxoplasma gondii infection (P21)

Mogib El-Rahman Khedr, Southampton: Pro-Inflammatory Actions of Human Mast Cell Tryptase in Mice Deficient in Protease Activated Receptor 2 (PAR2) (P22)

Anna James, Stockholm Sweden: Corticosteroid treatment selectively decreases mast cells in the smooth muscle and epithelium of asthmatic bronchi (P23)

Hilary S Whitworth, Southampton: Dipeptidyl Peptidase I: A novel marker of Allergic Reactions to Food (P24)

Michael Thorpe, Uppsala: The extended cleavage specificity of the mast cell chymase of the crab eating macaque (Macaca fascicularis) - an interesting animal model for the analysis of the in vivo function of the human mast cell chymase (P25)

Ida Waern, Uppsala: Mast cell chymase is a negative regulator of allergic sensitization in house dust mite induced airway inflammation (P26)

Jani Lappalainen, Helsinki: Viral RNA elicits an interferon response in mast cells (P27)

Work Group 2

Nurit Pereg-Azouz, Tel Aviv University: Functional Genomics Analysis of Mast Cell Exocytosis Reveals Isoform Specific Regulation by Rab GTPases (P28)

Vladimir A. Gimenez-Rivera, Berlin: Mast cells control chronic type IV allergic skin inflammation in mice (P29)

Angel Vodenicharov, Stara Zagora: Mast cells in porcine kidney interlobar arteries – a TEM study (P30)

Ralph Rühl, Debrecen: Lipidomic approach for analysis of eicosanoids and docosanoids in serum and PBMCs of atopic dermatitis patients (P31)

Marcus Maurer, Berlin: Establishment of a Bradykinin Skin Test as a Tool for Monitoring Pharmacologic Effects (P32)

Doina Mihaila, Iasi: Is there a pattern of mastocytes distribution within inflammatory diseases and tumoral processes? Observations upon a few cases (P33)

Chatterjea, D, St. Paul: Mast cell degranulation mediates compound 48/80-induced plantar thermal hypernociception and the local inflammatory response in mice (P34)

Anke Petzold, Dresden: Local clonal expansion of bone marrow-derived mast cell progenitors recruited into inflamed skin (P35)

Work Group 3

Ambili Menon, Karlsruhe: PEST–domain enriched tyrosine phosphatase is a positive regulator of anaphylaxis in mice (P36)

Catherine Vial, Leicester: Characterisation of the human mast cell line HMC-1 ectonucleotidase activity (P37)

Anton de Groot, Leiden: An adenoviral knock-down screen in primary human mast cells reveals novel targets for therapy in allergic rhinitis (P38)

Barbara Frossi, Udine: OX40L-engagement interferes with IgE/Ag-driven mast cell activation by selectively acting on Fyn, PI3K and RhoA (P39)
Fabio R Melo, Uppsala: Serglycin regulates apoptotic versus necrotic cell death in mast cells (P40)

Ulrich Blank, Paris: Munc18-2 controls granule translocation in mast cells through dynamic interactions with the fusion machinery and the microtubule cytoskeleton (P41)

Sabine Altrichter, Berlin: IgE mediated autoallergy against thyroid peroxidase – a novel pathomechanism of chronic spontaneous urticaria? (P42)

Anja Förster, Cologne: Differential regulation of apoptosis induced by anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in primary and neoplastic basophils: potential implications for treatment of basophilia associated with chronic myeloid leukemia and other hematologic malignancies (P43)

Erola Ainsua-Enrich, Barcelona: The adaptor 3BP2 is required for optimal high affinity IgE receptor signaling in human mast cells (P44)

Elin Rönnberg, Uppsala: Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner (P45)

Anders Lundequist, Uppsala: Differential regulation of nuclear receptor 4a subfamily following mast cell activation (P46)

Brice Korkmaz, Tours: Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates (P47)

Paulo De Sepulveda, Marseille: KIT-D816V oncogenic activity is maintained under control by the juxtamembrane docking site YY568-570 (P48)

Paulo De Sepulveda, Marseille: Mutant KIT receptor as a model to identify novel targets in mast cells (P49)

Work Group 4

Anca Chiriac, Iaşi: Transient disappearance of urticaria pigmentosa lesions during Enoxaparinum treatment: A case report (P50)

Daniele De Filippis, Naples: Palmitoylethanolamide ameliorates contact allergic dermatitis in mice: involvement of mast cells and endocannabinoids (P51) 

Krisztina V. Vukman, Dublin: Tegumental antigens of Fasciola hepatica (FhTeg) suppress inflammatory immune response in mast cells (P52)

AB Penissi, Mendoza: Phenolic molecules from olive oil inhibit rat peritoneal mast cell activation (P53)

Laila Karra, Jerusalem: Dexamethasone influences CD300a inhibitory receptor function on human and murine mast cells (P54)

Jane Spirkoski, Uppsala: Mast cells are sensitive to apoptosis induced by the sigma 2 receptor agonist siramesine (P55)

Jane A Warner, Southampton: Mast cells in the proximal and distal airways: Effects of steroids (P56)

Laurie CK Lau, Southampton: Inhibition of mast cell mediator release in the presence of honey (P57)

Marc Freichel, Heidelberg: Regulation of mast cell activation by TRP protein-mediated Ca2+ entry (P58)

Tilo Biedermann, Tübingen: Co-factor dependent anaphylaxis triggered by innate immune signals is mediated by basophils (P59)

Ivana Hálová, Prague: Involvement of tetraspanin CD9 in mast cell signaling and chemotaxis (P60)

 

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